Coronavirus - UK
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@Tim said in Coronavirus - UK:
@Bones Think it's a two dose vaccine as well.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext
Think you're right. It's a weird one, apparently half a standard first dose gives a higher level of protection than two full doses. Think they are waiting for final trials/approval before deciding the best way to roll it out.
They are looking at delaying giving people the second shot of the Pfizer vaccine to get a wider level of immunity into the community
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@Victor-Meldrew said in Coronavirus - UK:
Think you're right. It's a weird one, apparently half a standard first dose gives a higher level of protection than two full doses
That's something that was a small error subset of the clinical trials, and should never have been reported, let a lone released by the pharmaceutical company. That claim has no scientific validity.
On the other hand, that's not entirely unexpected given the immunogenicity of attenuated addeno virus.
(I do some work in gene therapy)
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@Tim said in Coronavirus - UK:
That's something that was a small error subset of the clinical trials, and should never have been reported
Why am I not surprised? Still being reported by the BBC
(I do some work in gene therapy)
Sanger Institute? Ms M1 does some work there.
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@Victor-Meldrew said in Coronavirus - UK:
@R-L
There's positive stuff. Vaccines are rolling out quite fast in the NHS according to Mrs M's daughter and Care Home residents have started getting it.
Oxford Vaccine has been submitted for approval which is expected just after Christmas. Much easier to manufacture and handle than the Pfizer one and the UK has 100m doses ordered.
From Jan 4 Punters can go to the races and get an Oxford jab at same visit. Aiming to do 1m plus a week.
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@Tim said in Coronavirus - UK:
@Bones Think it's a two dose vaccine as well.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext
One dose 60% effective. Two up to 90%.
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@Victor-Meldrew said in Coronavirus - UK:
@R-L
There's positive stuff. Vaccines are rolling out quite fast in the NHS according to Mrs M's daughter and Care Home residents have started getting it.
Oxford Vaccine has been submitted for approval which is expected just after Christmas. Much easier to manufacture and handle than the Pfizer one and the UK has 100m doses ordered.
It can be kept at normal fridge temperature and is being produced at cost. Oxford University control the intellectual property and there's public benefit clause in their charter. Only conceivable COVID-19 vaccine for most of the world's population.
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Also read that AstroZeneca, who own the IP for production processes, are charging richer countries for the vaccine and using that to subsidise production and distribution to poorer countries. It's cheap at £2 a dose too compared to £15 for the Pfizer one
I see the EU delayed vaccination for 6 days so it can start in EU countries at the same time - to provide "a touching show of European unity". WTF?
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@Victor-Meldrew said in Coronavirus - UK:
Also read that AstroZeneca, who own the IP for production processes, are charging richer countries for the vaccine and using that to subsidise production and distribution to poorer countries. It's cheap at £2 a dose too compared to £15 for the Pfizer one
I see the EU delayed vaccination for 6 days so it can start in EU countries at the same time - to provide "a touching show of European unity". WTF?
We’re all in this together. 😳 obviously more so for the people that die in the meantime.
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@Victor-Meldrew said in Coronavirus - UK:
Also read that AstroZeneca, who own the IP for production processes, are charging richer countries for the vaccine and using that to subsidise production and distribution to poorer countries. It's cheap at £2 a dose too compared to £15 for the Pfizer one
I see the EU delayed vaccination for 6 days so it can start in EU countries at the same time - to provide "a touching show of European unity". WTF?
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@Catogrande said in Coronavirus - UK:
We’re all in this together. obviously more so for the people that die in the meantime.
I read somewhere that German doctors were furious they had the vaccine but were barred from administering it until the EU Commission gave the go-ahead.
The EU turned down the chance to buy large quantities of the Oxford and Moderna vaccines and instead bet on one being developed by a French company which has flopped. Talk about xenophobia in a global pandemic..
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@Victor-Meldrew said in Coronavirus - UK:
@Catogrande said in Coronavirus - UK:
We’re all in this together. obviously more so for the people that die in the meantime.
I read somewhere that German doctors were furious they had the vaccine but were barred from administering it until the EU Commission gave the go-ahead.
The EU turned down the chance to buy large quantities of the Oxford and Moderna vaccines and instead bet on one being developed by a French company which has flopped. Talk about xenophobia in a global pandemic..
When you hear this of this sort of shit going on you can quite understand the Brexit POV.
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@Catogrande said in Coronavirus - UK:
When you hear this of this sort of shit going on you can quite understand the Brexit POV.
I would have hoped, had we still been part of the EU, we'd have told them to fuck right off for putting lives at risk for the sake of "EU Unity"
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@Victor-Meldrew said in Coronavirus - UK:
@Catogrande said in Coronavirus - UK:
We’re all in this together. obviously more so for the people that die in the meantime.
I read somewhere that German doctors were furious they had the vaccine but were barred from administering it until the EU Commission gave the go-ahead.
The EU turned down the chance to buy large quantities of the Oxford and Moderna vaccines and instead bet on one being developed by a French company which has flopped. Talk about xenophobia in a global pandemic..
Worse than that, as the article I posted notes, De Spiegel reported the EU ordered only 200m of the 500m doses offered, in anticipation of the French vaccine being available. Luckily the British vaccine will be there to save their bacon!
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@Victor-Meldrew said in Coronavirus - UK:
@Catogrande said in Coronavirus - UK:
When you hear this of this sort of shit going on you can quite understand the Brexit POV.
I would have hoped, had we still been part of the EU, we'd have told them to fuck right off for putting lives at risk for the sake of "EU Unity"
We did retain control over certain issues, money and health being the two big ones. So quite likely we would have ploughed our own furrow.
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Don’t forget Boris took a contrary / fuck you stance to what the EU was doing back in March so it’s not as rosy a picture as everyone is painting.
There have been massive blunders both sides of the Channel.
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@MiketheSnow Agreed
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@MiketheSnow whose painting a rosy picture?
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@MajorRage said in Coronavirus - UK:
@MiketheSnow whose painting a rosy picture?
MSM posted in this thread
Deflection
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@pakman said in Coronavirus - UK:
@Tim said in Coronavirus - UK:
@Bones Think it's a two dose vaccine as well.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext
One dose 60% effective. Two up to 90%.
Getting scientific here, but the reason that they accidentally gave half doses in the AstraZeneca trial has just been released. The Italian manufacturers used a method called qPCR to confirm the strength (potency) of the drug supplied, which is the correct way to do that. Oxford when they received it, did their own tests using a different method (NANODROP), determined that the drug was twice the potency that it was, trusted their own results and watered it down accordingly.
Pretty bad process to assume the test you did is right (especially when NANODROP is typically used just for spot checks, not full quality control), and then not to bother checking with the manufacturers at all, or testing via qPCR (which is not very time consuming), then just going ahead and trusting your own results in isolation.
Through such fuckups are scientific breakthroughs made...
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@Victor-Meldrew said in Coronavirus - UK:
I read somewhere that German doctors were furious they had the vaccine but were barred from administering it until the EU Commission gave the go-ahead.
Imagine just handing over your sovereignty like that.