Coronavirus - Overall
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Next level down is (https://www.ox.ac.uk/news/2021-06-16-recovery-trial-finds-regeneron-s-monoclonal-antibody-combination-reduces-deaths) so you can read more... "p? huh?"ie my university stage 2 stats has long faded from memory but...
"Among patients who were seronegative at baseline (the primary analysis population for this comparison), the antibody combination significantly reduced the primary outcome of 28-day mortality by one-fifth compared with usual care alone (24% of patients in the antibody combination group died vs 30% of patients in the usual care group; rate ratio 0·80; 95% confidence interval 0·70–0·91; p=0·001). Thus, for every 100 such patients treated with the antibody combination, there would be six fewer deaths"
Joe Rogan wouldn't get this on the NHS and I really doubt if UK private healthcare insurance policies would cover it either.
UK "RECOVERY" trial program has imho been bloody good. Think they were the first to really prove clinically that (cheap and readily available) corticosteroids had a significant impact on reducing death rates. Unfortunately there's no narrative or £1000 a pop sales angle there for Big Pharma.
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@tim Every little helps, marginal gains yeah.
The only major advancements I've heard of in non-vaccine medical treatments worldwide have been dexamethosone (the corticosteroid I mentioned) identified in another early UK RECOVERY clinical trial which "found that dexamethasone reduced the risk of dying by one-third in ventilated patients and by one fifth in other patients receiving oxygen only. There was no benefit among those who did not need respiratory intervention"
Plus moving to non-invasive oxygen much earlier in treatments i.e. only using mechanical ventilators as a real last resort.
Both of these are really now just part of the worldwide CoVid treatment playbook.
Remdesvir seems to have as much impact on mortality of people hospitalised as horse tablets and anti-malaria drugs. Safer than bleach though.
Has there been anything else I missed, crackpot theories aside?
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An Iceland update.
They were averaging about 25 in ICU last time I looked, now down to 10.
1% Serious or Critical in current wave:
As for controls to combat the wave. Looks like 200 person limit for gatherings and one-metre distancing rule, and border testing.
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@taniwharugby said in Coronavirus - Overall:
@rapido sorry, I must have missed an earlier post, what is Iceland doing differently?
Sweden is another who have taken on Covid differently too.
Nothing much.
They are highly vaccinated, had eliminated locally, then had a delta outbreak when already well vaxxed. Obviously will not try (very hard) to re-eliminate.
I suspect the NZ govt will be looking at them closely for what to expect and what to follow if NZ succeeds in eliminating again, vaccinating fully, and then re-opening.
Hence, I follow them.
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@tim said in Coronavirus - Overall:
This is a pretty good piece aimed at laymen about why decline in antibody levels is overstated as a concern for vaccination:
Thanks, I've read similar but good one.
I admit I always wonder if the whole booster thing is Pfizer driving up sales (they are always in the press). I agree it's probably needed for elderly and vulnerable whatever vaccine you have ... we already do that for Flu, I wouldn't argue it's a very very sensible precaution.
Beyond that I think it's early days, evidence is very initial, and may be vaccine/vaccine technology dependent ...
Selfishly, if offered a booster, yeah I'd take it. Belt-and-braces ...
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Enter Sandman.
I count about two or three masks. They’re either back to normal, given up, or really don’t giveafuck any more.
Good times.
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@kid-chocolate always amazed at thier stadiums and attendance!
Thats crazy for a college game (googled >65,000 capacity)
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@kid-chocolate wrong thread, but one day I'd love to go and see a few NCAA games in early autumn. Would be sensational - and VT with their entry would be on the list. It just looks like it's going off there
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@taniwharugby The likes of Michigan State and Ohio State have stadiums with capacities in excess of 100,000.
Having been to a few college football games myself in a 70,000 capacity stadium you can be a long way from the field and the players look like ants.
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@nzzp said in Coronavirus - Overall:
@kid-chocolate wrong thread, but one day I'd love to go and see a few NCAA games in early autumn. Would be sensational - and VT with their entry would be on the list. It just looks like it's going off there
I did my undergraduate internship at Iowa State, working with the Athletics Dept.
Was allowed to ‘suit up’ (support staff, lots of polyester) for the Iowa State v Iowa game and got to watch the match from the touch line.
55,000 crowd
Immense noise from the crowd
Hits were like gun shots
Will never forget it
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@bovidae said in Coronavirus - Overall:
@taniwharugby The likes of Michigan State and Ohio State have stadiums with capacities in excess of 100,000.
Spartan Stadium holds about 75K. You’re thinking of “The Big House” (Michigan Stadium) in Ann Arbor, which has 110K capacity and has seated up to 115,000. EVERY game, going back prob 30-40 years at least, is a sellout.
Do not confuse Spartans and Wolverines. Fightin’ words!!
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@snowy said in Coronavirus - Overall:
@tim said in Coronavirus - Overall:
COVID renews interest in radiation, but doctors caution against pilgrimages to radon-filled mines
What a world.
Yep. Easier ways.
Build a stone / granite house and get it all the time. Move to Rome. Radon all over the place. No need to sit in a bloody mine.
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I'm behind on all the COVID news, can someone udate me on the correlation between COVID fatalities and hospitalization to obesity? Just wondering why, extra stress on the heart or compression on lungs, perhaps?
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@nostrildamus said in Coronavirus - Overall:
I'm behind on all the COVID news, can someone udate me on the correlation between COVID fatalities and hospitalization to obesity? Just wondering why, extra stress on the heart or compression on lungs, perhaps?
My uneducated unscientific guess is that obesity is probably awful for every virus and ailment known to man. My guess is obesity — morbid obesity — is the real silent killer. If some of what Sgt Hartman called Private Pyle “disgusting fatbodies” spent more time dieting and on a treadmill the past year and a half all our societies would be better protected in the public health sphere. But what do I know? Guvment and media tells me I’m a fat-shaming bigot hater and to shutup, bend over and take the vaxx.
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@kid-chocolate said in Coronavirus - Overall:
Guvment and media tells me I’m a fat-shaming bigot hater and to shutup, bend over and take the vaxx.
Your doctor must really like you. Mine just asked for my arm.
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@kid-chocolate said in Coronavirus - Overall:
@nostrildamus said in Coronavirus - Overall:
I'm behind on all the COVID news, can someone udate me on the correlation between COVID fatalities and hospitalization to obesity? Just wondering why, extra stress on the heart or compression on lungs, perhaps?
My uneducated unscientific guess is that obesity is probably awful for every virus and ailment known to man. My guess is obesity — morbid obesity — is the real silent killer. If some of what Sgt Hartman called Private Pyle “disgusting fatbodies” spent more time dieting and on a treadmill the past year and a half all our societies would be better protected in the public health sphere. But what do I know? Guvment and media tells me I’m a fat-shaming bigot hater and to shutup, bend over and take the vaxx.
Obesity is one risk factor, but if you're talking about the overall risk of death from CoVid in society, it's really a relatively minor risk factor compared with age.
This is the OpenSafely analysis of the the medical records of 17million+ UK adults aged 18 upwards cross-referenced to 10,000+ deaths in the UK. So a pretty good sample. OpenSafely is an academic collaboration between our NHS Health Service, University of Oxford and other institutions (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611074/)
Hope it helps paint a broad picture on CoVid risk factors.
Not sure this is a binary decision, perhaps your safest approach is both staying slim and being vaxxed too??