Coronavirus - Overall
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What he claimed to have used:
In his video on Wednesday, Mr. Rogan said he had been treated with a series of medications. “Sunday sucked,” he said, but by the time he made the video, he said he was feeling “pretty good,” using an expletive.
“A wonderful heartfelt thank you to modern medicine for pulling me out of this so quickly and easily,” he said.
The list of treatments he mentioned included monoclonal antibodies, which have been shown to protect Covid patients at risk of becoming gravely ill; and prednisone, a steroid widely accepted as a Covid treatment. When Donald J. Trump was stricken with Covid during his presidency, he was also treated with monoclonal antibodies.
Mr. Rogan also said he had received a “vitamin drip” as well as ivermectin, a drug primarily used as a veterinary deworming agent. The Food and Drug Administration has warned Covid-19 patients against taking the drug, which has repeatedly been shown as ineffective for them in clinical trials. However, it is a popular subject on Facebook, Reddit and among some conservative talk show hosts, and some toxicologists have warned of a surge of reports of overexposure to the drug by those who obtain it from livestock supply stores.
I think I read somewhere that it was the Regeneron mAbs he was administered.
The cost of Regeneron infusions: about $1,250 a dose. For now, the federal government is covering the cost.
The federal government is also covering the costs of covid vaccination, at about $20 a dose.
Hospitals and infusion centers also charge for the time- and resource-intensive administration of monoclonal antibody treatment. Medicare has agreed to pay providers between $310 and $450 for performing it in health care settings — and $750 for treatment in a patient’s home.
Some patients who receive the treatment may be charged similar amounts for copays and administration fees, depending on what a hospital charges and what their insurance covers. DeSantis has emphasized that the treatment is provided at no cost to patients at Florida’s state-run sites.
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Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced positive topline results from the largest trial to date assessing a COVID-19 treatment in infected non-hospitalized patients (n=4,567). This definitive Phase 3 outcomes trial in high-risk non-hospitalized COVID-19 patients ("outpatients") met its primary endpoint, showing the investigational REGEN-COV™ (casirivimab with imdevimab) significantly reduced the risk of hospitalization or death by 70% (1,200 mg intravenous [IV]) and 71% (2,400 mg IV) compared to placebo.
No mention of vax status, and looks like none had the delta variant.
Will be interesting if this can help immunocompromised people who can't develop immunity from vaccination.
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@canefan said in Coronavirus - Overall:
@taniwharugby said in Coronavirus - Overall:
@mikethesnow my sister in law and her husband (in UK) got it last at start of this year, I'd say they are not particularly healthy (not overly unhealthy either) but both got over it after a few days, none of thier 3 kids got it off them.
If you are lucky, you're lucky. I'd feel differently if I ended up being one of the statistics
I guess Wales is the luckiest country on earth then, because I know a fuck load more people who have had it and are fine compared with those who had it and passed away.
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@mikethesnow said in Coronavirus - Overall:
@canefan said in Coronavirus - Overall:
@taniwharugby said in Coronavirus - Overall:
@mikethesnow my sister in law and her husband (in UK) got it last at start of this year, I'd say they are not particularly healthy (not overly unhealthy either) but both got over it after a few days, none of thier 3 kids got it off them.
If you are lucky, you're lucky. I'd feel differently if I ended up being one of the statistics
I guess Wales is the luckiest country on earth then, because I know a fuck load more people who have had it and are fine compared with those who had it and passed away.
What would you know, you've only had it and seen many others have it.
In NZ, they know the right way.
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@mariner4life despite having a bit of a crush on him, he's a moron. Cup of lemsip and you'll be fine lad, should have just got on with it.
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@tim said in Coronavirus - Overall:
Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced positive topline results from the largest trial to date assessing a COVID-19 treatment in infected non-hospitalized patients (n=4,567). This definitive Phase 3 outcomes trial in high-risk non-hospitalized COVID-19 patients ("outpatients") met its primary endpoint, showing the investigational REGEN-COV™ (casirivimab with imdevimab) significantly reduced the risk of hospitalization or death by 70% (1,200 mg intravenous [IV]) and 71% (2,400 mg IV) compared to placebo.
No mention of vax status, and looks like none had the delta variant.
Will be interesting if this can help immunocompromised people who can't develop immunity from vaccination.
It has recently been approved in the UK, as you say, essentially for immuno compromised folk who can't take the vaccine.
It's fricken expensive though, and as Reuters report it, the UK healthcare regulators position states that "The drug is not intended to be used as a substitute for vaccination, the MHRA said"
I saw £1000-£2000 cost to the NHS per treatment quoted in another newspaper
As its been UK trialled and approved so recently, the clinical tests should include Delta. I'll have a dig.
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@mariner4life said in Coronavirus - Overall:
Joe Rogan is a fucking retard. Joe Rogan is the dumb person's view of a smart guy. Joe Rogan is your mate's stoner older brother who talks about aliens and conspiracies and shit
in short, fuck Joe Rogan
There is probably some truth in this, but when I can be bothered, I do enjoy his casts. But I'm certainly no fanboy who has 2-3 hours to listen to people speak on a very routine basis.
When he talks pot, hunting though, it's an immediate switch off.
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UK RECOVERY investigators found REGEN-COV reduced risk of death by 20% in patients hospitalized with COVID-19 who had not mounted their own immune response (primary outcome for the primary analysis population)... Between September 18, 2020 and May 22, 2021, 9,785 patients hospitalized with COVID-19 were randomly allocated to receive usual care plus REGEN-COV (8,000 mg by intravenous infusion) or usual care alone as part of the RECOVERY trial. Usual care was determined by individual facilities and clinicians, and could include steroids and remdesivir. Follow-up is complete for 99% of participants.
My bolding...
Dates mentioned suggest not much Delta, so essentially a 20% reduction in mortality against the less dangerous Alpha is my interpretation.
I don't even remember this reported in the UK media (???) , probably as its niche and expensive and the focus needs to be on vaccination.
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Next level down is (https://www.ox.ac.uk/news/2021-06-16-recovery-trial-finds-regeneron-s-monoclonal-antibody-combination-reduces-deaths) so you can read more... "p? huh?"ie my university stage 2 stats has long faded from memory but...
"Among patients who were seronegative at baseline (the primary analysis population for this comparison), the antibody combination significantly reduced the primary outcome of 28-day mortality by one-fifth compared with usual care alone (24% of patients in the antibody combination group died vs 30% of patients in the usual care group; rate ratio 0·80; 95% confidence interval 0·70–0·91; p=0·001). Thus, for every 100 such patients treated with the antibody combination, there would be six fewer deaths"
Joe Rogan wouldn't get this on the NHS and I really doubt if UK private healthcare insurance policies would cover it either.
UK "RECOVERY" trial program has imho been bloody good. Think they were the first to really prove clinically that (cheap and readily available) corticosteroids had a significant impact on reducing death rates. Unfortunately there's no narrative or £1000 a pop sales angle there for Big Pharma.
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@tim Every little helps, marginal gains yeah.
The only major advancements I've heard of in non-vaccine medical treatments worldwide have been dexamethosone (the corticosteroid I mentioned) identified in another early UK RECOVERY clinical trial which "found that dexamethasone reduced the risk of dying by one-third in ventilated patients and by one fifth in other patients receiving oxygen only. There was no benefit among those who did not need respiratory intervention"
Plus moving to non-invasive oxygen much earlier in treatments i.e. only using mechanical ventilators as a real last resort.
Both of these are really now just part of the worldwide CoVid treatment playbook.
Remdesvir seems to have as much impact on mortality of people hospitalised as horse tablets and anti-malaria drugs. Safer than bleach though.
Has there been anything else I missed, crackpot theories aside?
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An Iceland update.
They were averaging about 25 in ICU last time I looked, now down to 10.
1% Serious or Critical in current wave:
As for controls to combat the wave. Looks like 200 person limit for gatherings and one-metre distancing rule, and border testing.
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@taniwharugby said in Coronavirus - Overall:
@rapido sorry, I must have missed an earlier post, what is Iceland doing differently?
Sweden is another who have taken on Covid differently too.
Nothing much.
They are highly vaccinated, had eliminated locally, then had a delta outbreak when already well vaxxed. Obviously will not try (very hard) to re-eliminate.
I suspect the NZ govt will be looking at them closely for what to expect and what to follow if NZ succeeds in eliminating again, vaccinating fully, and then re-opening.
Hence, I follow them.
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@tim said in Coronavirus - Overall:
This is a pretty good piece aimed at laymen about why decline in antibody levels is overstated as a concern for vaccination:
Thanks, I've read similar but good one.
I admit I always wonder if the whole booster thing is Pfizer driving up sales (they are always in the press). I agree it's probably needed for elderly and vulnerable whatever vaccine you have ... we already do that for Flu, I wouldn't argue it's a very very sensible precaution.
Beyond that I think it's early days, evidence is very initial, and may be vaccine/vaccine technology dependent ...
Selfishly, if offered a booster, yeah I'd take it. Belt-and-braces ...
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Enter Sandman.
I count about two or three masks. They’re either back to normal, given up, or really don’t giveafuck any more.
Good times.
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@kid-chocolate always amazed at thier stadiums and attendance!
Thats crazy for a college game (googled >65,000 capacity)
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@kid-chocolate wrong thread, but one day I'd love to go and see a few NCAA games in early autumn. Would be sensational - and VT with their entry would be on the list. It just looks like it's going off there